Immune Imprinting in the Influenza Ferret Model
Abstract
The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations. Animal models that are used to investigate influenza pathogenesis and vaccination do recapitulate the pre-immune history in the human population. The establishment of influenza pre-immune ferret models is necessary for understanding infection and transmission and for designing efficacious vaccines.
Type
Publication
Vaccines
Authors
Amanda Skarlupka
(she/her)
Senior Program Manager at Vivli
I’m an infectious disease and data scientist advancing public health
through ethical, FAIR, and impactful data sharing. At Vivli, I lead
member engagement and strategic planning for the Antimicrobial
Resistance (AMR) Register and serve as a subject matter expert in data
governance and international data sharing. My work bridges researchers,
clinicians, and data scientists to drive innovation in health equity,
AI ethics, and open science.